Reserve directly with us
Up to 10% cheaper
than with Booking.com
Check rooms and rates
From157US$ /night
Check-in
22Dec2025Select date
Check-out
23Dec2025Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

1108 West Main Street, Durham, North Carolina, United States, 27701
-
Close to Trinity Park
Great
8.2
/10
4.3
/5

Spacious Suite Accommodations

Residence Inn Durham offers 147 air-conditioned suites with separate living, cooking, and sleeping areas. Each suite includes a full kitchen with a stovetop, full-sized refrigerator/freezer, dishwasher, and cookware. Rooms feature ergonomic workstations, free Wi-Fi, and private bathrooms with showers or baths. Select suites include a seating area and sofa bed.

Complimentary Breakfast Daily

Guests receive a free full American hot breakfast served daily. For other meals, each suite's kitchen allows for self-catering. Grocery delivery service is available for ingredients. The hotel hosts a complimentary reception with snacks and drinks on select days.

Indoor Pool and Fitness

The hotel features an indoor heated pool and a 24-hour fitness center with cardio equipment and free weights. The property includes a fireplace in the lobby and offers grocery deliveries, luggage storage, and meeting facilities.

Near Duke University

Located in Downtown Durham, the hotel is near Duke University, North Carolina Central University, and Durham Performing Arts Center. It is 1 mile from Durham Bulls Athletic Park, 1.5 miles from American Tobacco Historic District, and 11.5 miles from University of North Carolina. The complimentary area shuttle serves nearby destinations with 24-hour advance reservation.

Business and Guest Services

The hotel provides 2,528 square feet of meeting space across five venues with AV equipment. Services include express check-in/check-out, a business center, wedding services, dry cleaning, and mobile key access. The property is pet-friendly with fees starting at $100 for 1-7 days and offers wheelchair-accessible rooms and facilities.

Must-do experiences

  • Savor a pulled pork sandwich at The Pit Authentic Barbecue.
  • Stroll through the Sarah P. Duke Gardens for beautiful views.
  • Catch a show at the historic Carolina Theatre downtown.
  • Explore the Nasher Museum of Art for its impressive collection.
  • Visit the Durham Farmers' Market on Saturdays for local goodies.
View all

Choose the Room

From cosy doubles to spacious family suites – all with flexible options, breakfast, and exclusive deals.
King Studio
2 persons
45 m² 
1 King-size bed
Shower
Coffee machine
Queen Studio Sofa Bed
2 persons
40 m² 
1 King-size bed
Shower
Coffee machine
One-Bedroom Suite
2 persons
44 m² 
1 King-size bed and 1 Sofa bed
Coffee machine
Heating
1 Bedroom Suite 1 King or 1 Queen Sofa bed Mobility Accessible w or Roll Shower
2 persons
39 m² 
Click button to see more rooms
Show all rooms
Show all roomsLess

Check Dates & Room Rates

See what's available for your travel dates

Amenities

Thoughtfully designed amenities for a comfortable & memorable stay

General

  • No smoking on site
  • Free Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Lift
  • Fireplace
  • Smoke detectors
  • Fire extinguishers
  • Key card access
  • Key access

Sports & Fitness

  • Fitness centre

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Free shuttle service
  • Car hire
  • Laundry
  • Dry cleaning
  • Grocery shopping service
  • Shops/Commercial services

Dining

  • Bar/ Lounge area
  • Picnic area/ Tables

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Spa & Leisure

  • BBQ facilities
  • Leisure/ TV room

Room features

  • Air conditioning
  • Heating
  • Sitting area
  • Terrace
  • Garden furniture

Self-catering

  • Cookware/ Kitchen utensils
Show more

Location

1108 West Main Street, Durham, North Carolina, United States, 27701
Map view
1108 West Main Street, Durham, North Carolina, United States, 27701
Nearby
Bridge
11 foot 8 Bridge
350 m
North Carolina Eye & Ear Hosp
130 m
Bridge
11'8"
350 m
Christian and Missionary Alliance Community Church
350 m
Church
Immaculate Conception Catholic Church
350 m
Duke University Museum of Art
540 m
Restaurants
Papa John's
200 m
1018 W Main St
Toast
960 m
345 West Main Street
King's Sandwich Shop
1.2 km
701 Foster Street
Cocoa Cinnamon
1.3 km
420 West Geer Street
Explore Durham
Explore Durham
Top Attractions
Activities
Dining
Entertainment
Duke University Chapel
25 minutes' walk
Gothic architecture and stunning stained glass make this chapel a must-visit for its beauty and historical significance.
American Tobacco Campus
18 minutes' walk
A vibrant area with dining, shopping, and entertainment options, plus beautiful river views and historic tobacco factories.
Durham Bulls Athletic Park
20 minutes' walk
Home of the Triple-A Durham Bulls, this park offers an exciting atmosphere for baseball lovers and families alike.
Museum of Durham History
10 minutes' walk
Showcasing Durham's unique heritage, this museum features exhibits on local history, culture, and significant events.
Jordan Lake Game Lands
5 minutes' drive
Outdoor enthusiasts will enjoy hiking, birdwatching, and fishing in this scenic lake area, great for tranquility or adventure.
Museum of Life and Science
35 minutes walking
An engaging science museum with interactive exhibits and outdoor exhibits, suitable for families and curious minds of all ages.
Toast
12 minutes' walk
A cozy eatery offering gourmet breakfast and brunch, known for its fresh, local ingredients and inviting atmosphere.
Durham Farmer's Market
15 minutes' walk
Open on Saturdays, this market features local produce, handmade products, and a lively atmosphere perfect for a casual meal.
Durham Performing Arts Center
20 minutes' walk
A premier venue for theater and concerts, featuring a diverse lineup of performances, ideal for art and culture enthusiasts.
Carolina Theatre
15 minutes' walk
A historic venue hosting films, concerts, and events, providing a charming atmosphere for a fun night out.
Getting around
City Centre
Durham18 min  ·  1.5 km
Airports
Raleigh-Durham International Airport (RDU)38 min  ·  25.0 km
Danville Regional Airport (DAN)138 min  ·  91.6 km
Unlock Early-Bird Deals
Grab Exclusive Rates Instantly
Check Rates
Property information and rules
Check-in
from 15:00-23:59
Check-out
until 12 pm
Guest Parking
Public parking is possible on site at USD 15 per day.
Internet
is available in for free.
Breakfast
A buffet breakfast is served and charges are applicable. 
Children & extra beds
There are no extra beds provided in a room.  There are no cots provided in a room. 
Pets
Pets are allowed on request.
Number of floors:
4
Number of rooms:
126
Former name
residence inn durham mcpherson/duke university medical cntr
Questions of the users
About Residence Inn By Marriott Durham Duke University Medical Center Area
Is there a shuttle service available to nearby medical facilities?
15 November 2024
A shuttle service is typically offered to the hospital, but please note it is currently unavailable due to COVID-19 restrictions. It is expected to resume soon.
Are there special rates for families visiting patients at Duke Medical Hospital?
22 December 2024
Yes, discounted medical rates are provided for families of patients at Duke Medical Hospital.
Can guests access laundry facilities during their stay?
10 January 2025
Laundry services are available on-site for guests, with washing and drying priced at $1.50 each. The laundry area is located on the first floor.
Is there a cost associated with airport shuttle services?
5 February 2025
The estimated cost for an airport shuttle is approximately $40.
Are pets allowed in the hotel, and is there a fee?
20 March 2025
The hotel is pet friendly, with a fee of $100 per stay for up to two pets.
Does the hotel provide a breakfast service?
8 April 2025
Yes, a complimentary breakfast buffet is offered to all guests, ensuring a warm start to the day.
Are there monthly rates available for longer stays?
17 May 2025
Nightly rates are standard, but monthly rates may be possible. Contact the hotel's sales department for more details.
What activities and entertainment options are available on-site?
12 June 2025
Unfortunately, the hotel does not offer entertainment options on the property.
What amenities are available to assist guests with accessibility needs?
3 July 2025
The hotel features various accessible facilities including on-site parking, ramps, and accessible rooms with special features.
Is there free internet access for guests staying at the hotel?
18 August 2025
Yes, complimentary Wi-Fi is available for all guests.

Next best alternative

Consider them for your next trip.
Check-in
22Dec2025Select date
Check-out
23Dec2025Select date
Rooms and Guests2 Guests, 1 Room
Need more options?
Check Top hotels near Residence Inn By Marriott Durham Duke University Medical Center Area
Durham Marriott City Center Gym photo
Mobile-only price

Durham Marriott City Center

8.1
Great144 reviews
1030m from property
USD 125USD 112
per night
The Durham Hotel Interior photo
Mobile-only price

The Durham Hotel

7.5
Very good58 reviews
1110m from property
USD 225USD 202
per night
21C Museum Hotel Durham People photo
Mobile-only price

21C Museum Hotel Durham

7.8
Very good354 reviews
1116m from property
USD 120USD 108
per night